A novel one-pot synthesis of 2-arylpyrazoloquinolinone derivatives

Autor:	Mou Yung Yeh, Chun Hsi Chang, Yun Hwei Shen, Shaw Bing Wen, Ya Lan Wen, Fung Fuh Wong, En Chiuan Chang
Rok vydání:	2012
Předmět:	Chemistry Pinacol Organic Chemistry One-pot synthesis Intramolecular cyclization Biochemistry Combinatorial chemistry Cycloaddition Catalysis chemistry.chemical_compound Suzuki reaction Drug Discovery 1 3-Dipolar cycloaddition Structural isomer Organic chemistry
Zdroj:	Tetrahedron. 68:5920-5924
ISSN:	0040-4020
Popis:	Two regioisomers of 2-arylpyrazolo[3,4-c]quinolin-4(5H)-ones and 2-arylpyrazolo[4,3-c]quinolin-4(5H)-ones were synthesized by utilizing 3-arylsydnones, ethyl 3-bromopropynoate, and 2-aminophenylboronic acid pinacol ester in presence of catalytic agent Pd(PPh3)4. This efficient one-pot synthesis methodology involved 1,3-dipolar cycloaddition, Suzuki coupling reaction, and intramolecular cyclization three sequence steps.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2c2649906f84e4db618c0ac6252a18d3 https://doi.org/10.1016/j.tet.2012.04.093 Zobrazit plný text záznamu Full Text from ScienceDirect