Aminophosphonic Acids - Phosphorus Analogues of Natural Amino Acids.Part 1: Syntheses of α-Aminophosphonic Acids

Autor: Józef Drabowicz, Marcin H. Kudzin, Christian Stevens, Zbigniew H. Kudzin
Rok vydání: 2011
Předmět:
Zdroj: Current Organic Chemistry. 15:2015-2071
ISSN: 1385-2728
DOI: 10.2174/138527211795703612
Popis: This review presents a comprehensive account of methods which are commonly applied for the synthesis of alpha- aminophosphonic acids. In the following order, protocols based on the methodologies listed below are discussed: a) simultaneous formation of P-C-N systems; b) nucleophilic substitution with phosphoroorganic nucleophiles; c) additions of the P-H functions to multiple C-N bonds; d) alpha-amination of phosphonates and functionalized alkylphosphonates; e) modifications of the side chain of aminoalkylphosphonates; f) modifications of phosphorus functions and h) modifications of functions containing nitrogen.
Databáze: OpenAIRE