Cytotoxic Heptaketides from the Endolichenic Fungus Ulospora bilgramii
| Autor: | Fei Xie, Xiao-Yi Luan, Yun Gao, Ke Xu, Hong-Xiang Lou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
A549 cell Circular dichroism biology 010405 organic chemistry DNA damage Chemistry Organic Chemistry Pharmaceutical Science Fungus biology.organism_classification 01 natural sciences Molecular biology 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Apoptosis Cell culture Drug Discovery Molecular Medicine Cytotoxic T cell G1 phase |
| Zdroj: | Journal of Natural Products. 83:1623-1633 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.0c00108 |
| Popis: | Eleven new metabolites including nine heptaketides, ulosporin A-G (1a-7b), one diphenyl compound, ulophenol (8), and one spirobisnaphthalene, palmarumycin P5 (9), were isolated from the endolichenic fungus Ulospora bilgramii, which inhabits the lichen Umbilicaria sp. The structures of these compounds were elucidated based on comprehensive analysis of their spectroscopic, electronic circular dichroism (ECD), and single-crystal X-ray diffraction data. Ulosporin G (7) inhibited the growth of the human cancer cell lines A549, MCF-7, and KB with IC50 values of 1.3, 1.3, and 3.0 μM, respectively. Additionally, it induced A549 cell apoptosis through G0/G1 cell cycle arrest caused by DNA damage. |
| Databáze: | OpenAIRE |
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