29Si Isotope-Enriched Silicon Nanoparticles for an Efficient Hyperpolarized Magnetic Resonance Imaging Probe
| Autor: | Shivanand Pudakalakatti, Donghyuk Jo, Pratip K. Bhattacharya, Young Bok Lee, Hye Young Son, Sun-Joon Min, Yong Min Huh, Jiwon Kim, Seung-Hyun Yang, Chan-Gyu Joo, Nicholas Whiting, Hyeonglim Seo, Jeong Hyun Shim |
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| Rok vydání: | 2021 |
| Předmět: |
inorganic chemicals
Materials science medicine.diagnostic_test Silicon technology industry and agriculture chemistry.chemical_element Nanoparticle Depolarization Magnetic resonance imaging Nanotechnology equipment and supplies Porous silicon chemistry medicine General Materials Science Hyperpolarization (physics) Polarization (electrochemistry) Spectroscopy |
| Zdroj: | ACS Applied Materials & Interfaces. 13:56923-56930 |
| ISSN: | 1944-8252 1944-8244 |
| Popis: | Silicon particles have garnered attention as promising biomedical probes for hyperpolarized 29Si magnetic resonance imaging and spectroscopy. However, due to the limited levels of hyperpolarization for nanosized silicon particles, microscale silicon particles have primarily been the focus of dynamic nuclear polarization (DNP) applications, including in vivo magnetic resonance imaging (MRI). To address these current challenges, we developed a facile synthetic method for partially 29Si-enriched porous silicon nanoparticles (NPs) (160 nm) and examined their usability in hyperpolarized 29Si MRI agents with enhanced signals in spectroscopy and imaging. Hyperpolarization characteristics, such as the build-up constant, the depolarization time (T1), and the overall enhancement of the 29Si-enriched silicon NPs (10 and 15%), were thoroughly investigated and compared with those of a naturally abundant NP (4.7%). During optimal DNP conditions, the 15% enriched silicon NPs showed more than 16-fold higher enhancements─far beyond the enrichment ratio─than the naturally abundant sample, further improving the signal-to-noise ratio in in vivo29Si MRI. The 29Si-enriched porous silicon NPs used in this work are potentially capable to serve as drug-delivery vehicles in addition to hyperpolarized 29Si in vivo, further enabling their potential future applicability as a theragnostic platform. |
| Databáze: | OpenAIRE |
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