Mechanisms of histamine-releasing action of X-ray contrast media

Autor:	N. L. Shimanovskii, Yu. K. Napolov, Sergeev Pv
Rok vydání:	1996
Předmět:	X-ray contrast media chemistry.chemical_element General Medicine Calcium General Biochemistry Genetics and Molecular Biology In vitro Basophilic chemistry.chemical_compound chemistry Immunology Biophysics Incubation Histamine Whole blood
Zdroj:	Bulletin of Experimental Biology and Medicine. 122:1094-1098
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf02447655
Popis:	It is demonstratedin vitro that X-ray contrast media cause the release of histamine from rabbit basophilic leukocytes in a dose-dependent manner at 37°C. They are arranged in the following order of decreasing ability to induce the release of histamine: bilignost∼triombrast>peritrast∼ultravist>melitrast∼omnipaque. The extent to which basophils in whole blood are degranulated during incubation with any of these media is about 40% higher than that upon incubation of isolated leukocytes with these media. The release of histamine under the action of the contrast media is a Ca2+-dependent process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2bee2a48a8126c84f161a1d0ecd29b9a https://doi.org/10.1007/bf02447655 Zobrazit plný text záznamu Full text from SpringerLink