Erythema multiforme Associated with Autoreactivity to 17α-Hydroxyprogesterone

Autor:	Arala-Chaves M, Baló-Banga M, da Silva Mb, Porto Mt, Santos Ma, Pinto Js, Sobrinho L
Rok vydání:	1990
Předmět:	Chemotherapy Skin erythema business.industry medicine.medical_treatment Dermatology Human leukocyte antigen medicine.disease Thalidomide chemistry.chemical_compound chemistry Prednisone Immunology medicine Colchicine Hydroxyprogesterone Erythema multiforme business medicine.drug
Zdroj:	Dermatology. 180:146-150
ISSN:	1421-9832 1018-8665
DOI:	10.1159/000248015
Popis:	We report a case of a 23-year-old woman who was afflicted with disseminated skin erythema multiforme-like eruptions that started at the menarche, relapsed at the premenstrual periods, dramatically spread during two pregnancies and cleared after abortion; the skin lesions responded dramatically to thalidomide treatment. A high-affinity binding factor to 17α-hydroxyprogesterone (17-OHP) was found in the serum of this patient. Her lymphocytes did not proliferate in vitro after exposure to exogenous 17-OHP but showed significant chromatin activation. There was a decreased expression of HLA antigens at the surface of the patient’s blood lymphocytes. This is a unique well-documented case of erythema multiforme most possibly due to autoreactivity to 17-OHP; the precise mechanism(s) of this autoreactivity has not been established.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2becc9397cf4a732c1a45631c2e70aa8 https://doi.org/10.1159/000248015 Zobrazit plný text záznamu