Interaction of flurbiprofen sodium with cornea model monolayers at the air–water interface
| Autor: | M. L. García, M.A. Egea, M.A. Alsina, J. Valero, O. Valls |
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| Rok vydání: | 1997 |
| Předmět: |
Chromatography
Cholesterol Kinetics Metals and Alloys Flurbiprofen Sodium Surfaces and Interfaces Penetration (firestop) Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound medicine.anatomical_structure Membrane chemistry Chemical engineering Cornea Monolayer Materials Chemistry medicine Molecule lipids (amino acids peptides and proteins) |
| Zdroj: | Thin Solid Films. 301:169-174 |
| ISSN: | 0040-6090 |
| DOI: | 10.1016/s0040-6090(96)09589-2 |
| Popis: | In this work cornea lipid model monolayers, at the air–water interface, containing different percentages of cholesterol were developed. The different membrane models were characterized by the compression isotherms, compressibility and area per molecule values. The influence of cholesterol variations on the interaction of flurbiprofen sodium with the lipid monolayers was also studied, by penetration kinetics of the drug into the monolayers at different initial surface pressures (5, 10 and 20 mN m−1). The results obtained suggest that the cholesterol content is a factor to consider in the interaction of flurbiprofen sodium with the cornea models. |
| Databáze: | OpenAIRE |
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