Meniere's disease: histopathology, cytochemistry, and imaging
| Autor: | Akira Ishiyama, Gail Ishiyama, Ivan A. Lopez, Ali R. Sepahdari |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Pathology biology General Neuroscience biology.organism_classification medicine.disease General Biochemistry Genetics and Molecular Biology medicine.anatomical_structure History and Philosophy of Science Vertigo otorhinolaryngologic diseases medicine Cytochemistry Histopathology Inner ear Hair cell medicine.symptom Endolymphatic hydrops Tinnitus Meniere's disease |
| Zdroj: | Annals of the New York Academy of Sciences. 1343:49-57 |
| ISSN: | 0077-8923 |
| DOI: | 10.1111/nyas.12699 |
| Popis: | Meniere's disease is a poorly understood, disabling syndrome causing spells of vertigo, hearing fluctuation, tinnitus, and aural fullness. In this paper, we present a review of the histopathology, cytochemistry, and imaging of Meniere's disease. Histopathology is significant for neuroepithelial damage with hair cell loss, basement membrane thickening, and perivascular microvascular damage. Cytochemical alterations are significant for altered AQP4 and AQP6 expression in the supporting cell, and altered cochlin and mitochondrial protein expression. Current developments include imaging techniques to determine the degree and presence of endolymphatic hydrops, and future studies will endeavor to correlate the observance of hydrops with clinical findings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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