Modeling of Toxicological Effects of Fire Gases: I. Incapacitating Effects of Narcotic Fire Gases

Autor:	Harold L. Kaplan, Gordon E. Hartzell
Rok vydání:	1984
Předmět:	Smoke Toxicology Injury control Mechanics of Materials Narcotic Accident prevention Mechanical Engineering medicine.medical_treatment Environmental chemistry medicine Poison control Environmental science Safety Risk Reliability and Quality
Zdroj:	Journal of Fire Sciences. 2:286-305
ISSN:	1530-8049 0734-9041
DOI:	10.1177/073490418400200404
Popis:	Common fire gas toxicants fall into two major classes, narcosis-producing agents and irritants. It is desirable to model, mathematically, the effects of these common toxicants on humans exposed in a fire, and therefore, obviate the use of large numbers of laboratory animals in smoke toxicity testing. From a review of methodologies for assessment of the incapacitating effects of the nar cotic fire gases, it appears that rats are sensitive to approximately the same range of accumulated doses as may be deemed potentially hazardous to human subjects. This paper introduces an approach as a first approximation to the modeling of the incapacitating effects of the narcotic toxicants based on correla tion of observed effects with accumulated doses to which subjects are exposed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2be683db0157f2da9a8dcc2cabd814f2 https://doi.org/10.1177/073490418400200404 Zobrazit plný text záznamu