Expression of Mouse 17β-Hydroxysteroid Dehydrogenase/17-Ketosteroid Reductase Type 7 in the Ovary, Uterus, and Placenta: Localization from Implantation to Late Pregnancy1
| Autor: | Pirkko Vihko, Hellevi Peltoketo, Pasi Nokelainen, Mika Mustonen |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
0303 health sciences
medicine.medical_specialty urogenital system Decidua Uterus 030209 endocrinology & metabolism Ovary Estrone In situ hybridization Reductase Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology medicine.anatomical_structure Decidua Capsularis chemistry Internal medicine medicine Hydroxysteroid dehydrogenase reproductive and urinary physiology 030304 developmental biology |
| Zdroj: | Endocrinology. 141:772-778 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo.141.2.7309 |
| Popis: | Rodent 17β-hydroxysteroid dehydrogenase/17-ketosteroid reductase type 7 (17HSD/KSR7) catalyzes the conversion of estrone (E1) to estradiol (E2) and is abundantly expressed in the ovaries of pregnant animals in particular. In the present work we demonstrate cell-specific expression of 17HSD/KSR7 in the ovaries, uteri, and placentas of pregnant and nonpregnant mice using in situ hybridization. The results show that mouse 17HSD/KSR7 (m17HSD/KSR7) messenger RNA is distinctly and exclusively expressed in a proportion of corpora lutea (CLs). During pregnancy, expression of m17HSD/KSR7 is most abundant around embryonic day 14.5 (E14.5), when the ovaries are filled with CLs expressing 17HSD/KSR7. In the uterus, m17HSD/KSR7 is first detected on E5.5, when expression surrounds the implantation site on the antimesometrial side. As gestation progresses, m17HSD/KSR7 is expressed in the decidua capsularis on E8 and E9.5, disappearing thereafter from the antimesometrial decidua. On E9 onward, m17HSD/KSR7 messenger RNA e... |
| Databáze: | OpenAIRE |
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