Alkaloids with anti-human carbonic anhydrase isozyme II activity from the bulbs of Crinum asiaticum L. var. asiaticum
| Autor: | Ratchanaporn Chokchaisiri, Wachirachai Pabuprapap, Chulee Yompakdee, Anyaporn Sangkaew, Apichart Suksamrarn, Waraluck Chaichompoo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
High concentration
Inhibitory potential biology 010405 organic chemistry Chemistry Plant Science biology.organism_classification 01 natural sciences Biochemistry Isozyme Yeast 0104 chemical sciences 010404 medicinal & biomolecular chemistry Crinum asiaticum In vivo Carbonic anhydrase biology.protein Cytotoxicity Agronomy and Crop Science Biotechnology |
| Zdroj: | Phytochemistry Letters. 37:101-105 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2020.03.006 |
| Popis: | Two new haemanthamine-type alkaloids, crinasiaticine A (1) and crinasiaticine B (2), along with fifteen known alkaloids 3–17, were isolated from the bulbs of Crinum asiaticum L. var. asiaticum. The structures of the new compounds were established by spectroscopic analysis and the known compounds were identified by spectral comparison with those previously reported. All of the compounds were evaluated for their inhibitory potential against human carbonic anhydrase isozyme II (hCAII) in vivo activity using a novel yeast-based assay. Compounds 5 and 15 inhibited hCAII activity with minimal effective doses of 166 and 8.7 μM, respectively. These two compounds did not show cytotoxicity, even at the high concentration used. |
| Databáze: | OpenAIRE |
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