Elevated Umbilical Cord Cytokines are Related to Birth Size in HIV‐exposed and Unexposed Infants
| Autor: | Denna Michael, Joann M. McDermid, Aura Andreasen, Mark Urassa, Sarah H. Pedersen, John Changalucha, Safari Kinung’hi, Jim Todd, Amanda L. Wilkinson |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Fetus Cord Obstetrics business.industry Birth weight medicine.medical_treatment Intrauterine growth restriction Anthropometry medicine.disease Biochemistry Umbilical cord Proinflammatory cytokine Cytokine medicine.anatomical_structure Genetics medicine business Molecular Biology Biotechnology |
| Zdroj: | The FASEB Journal. 29 |
| ISSN: | 1530-6860 0892-6638 |
| Popis: | Background: Infection causes immune activation and inflammatory cytokines may be mediators of intrauterine growth restriction (IUGR). While infection and IUGR are common in developing regions, the intrauterine cytokine environment and its impact on birth size is undefined. Understanding the fetal environment mediated by multiple cytokines may inform interventions targeting birth anthropometry. Objective: To investigate the relationship between umbilical cord cytokines and birth size. Methods: Umbilical cord cytokines (IFN-γ, IL-1β, IL-2, IL-6, TNF-α, IL-12p70, IL-10, IL-13) were multiplexed from 50 singleton deliveries of women residing in rural Tanzania (38% HIV-positive). Birth weight and length were assessed using linear regression models adjusted for maternal age, nutritional status, HIV, and infant gender. Results: Cord IFN-γ, IL-1β, TNF-α, IL-12p70, and IL-10 were each associated with reduced birth weight (grams; -532, P |
| Databáze: | OpenAIRE |
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