A simple hydrazone probe for recognition of Al3+ and PPi and its applicability in lysosomal imaging

Autor:	Yu-Fei Song, Zhi-Hong Xu, Ming Li, Wei-Na Wu, Yuan Wang, Hai-Tao Zong, Hong-Xin Cai, Yun-Chang Fan
Rok vydání:	2022
Předmět:	Detection limit chemistry.chemical_classification Chemistry Hydrazone Combinatorial chemistry Fluorescence Pyrophosphate Atomic and Molecular Physics and Optics Analytical Chemistry chemistry.chemical_compound Morpholine Chelation Instrumentation Spectroscopy
Zdroj:	Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 268:120680
ISSN:	1386-1425
DOI:	10.1016/j.saa.2021.120680
Popis:	A simple hydrazone probe (1) was designed and synthesized for the successive detection of Al3+ and pyrophosphate (PPi) in almost 100% buffer environment. The probe provided O2N donor set for chelation with Al3+, leading to a distinct fluorescence boost at 510 nm. The in-situ formed 1-Al3+ complex detected PPi with an “on-off” behavior. The detection limits for Al3+ and PPi were 35.7 nM and 76 nM, respectively. Benefiting from the existence of morpholine as lysosome-targeting group, probe 1 was successfully applied to the detection of Al3+ and PPi in lysosomes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2bc7a56ad71f3521a4ab35a5be41ea0d https://doi.org/10.1016/j.saa.2021.120680 Zobrazit plný text záznamu Full Text from ScienceDirect