Possible involvement of mast-cell activation in aspirin provocation of aspirin-induced asthma

Autor: Masashi Kobayashi, Masami Taniguchi, Yukio Kawagishi, M. Kudoh, Mita H, Kazuo Akiyama, S. Endoh
Rok vydání: 2008
Předmět:
Zdroj: Allergy. 56:1061-1067
ISSN: 0105-4538
DOI: 10.1111/j.1398-9995.2001.00913.x
Popis: Background: Although there is increasing evidence of the importance of cysteinyl leukotrienes (LT) as mediators of aspirin-induced bronchoconstriction in aspirin-sensitive asthma, the cellular origin of the LT is not yet clear. Methods: Urinary concentrations of leukotriene E 4 (LTE 4 ), 11-dehydrothromboxane B 2 , 9α,11β-prostaglandin F 2 , and N τ -methylhistamine were measured during the 24 h following cumulative intravenous administration of increasing doses of lysine aspirin to asthmatic patients. In addition, the urinary concentrations of these metabolites were measured on 5 consecutive days in a patient who suffered an asthma attack after percutaneous administration of nonsteroidal anti-inflammatory drugs. Results: In aspirin-induced asthma patients (AIA, n = 10), the basal concentration of urinary LTE 4 , but not the other metabolites, was significantly higher than that in aspirin-tolerant asthma patients (ATA, n = 10). After intravenous aspirin provocation, the AIA group showed a 13.1-fold (geometric mean) increase in excretion of LTE 4 during the first 3 h, and 9α,11 β-prostaglandin F 2 also increased in the AIA group during the first 0-3 h and the 3-6 h collection period. N τ -methylhistamine excretion was also increased, but to a lesser degree. Administration of aspirin caused significant suppression of 11-dehydrothromboxane B 2 excretion in both the AIA and ATA groups. When the percentage of maximum increase of each metabolite from the baseline concentrations was compared between the AIA group and the ATA group, a significantly higher increase in excretion of LTE 4 , 9α,11β-prostaglandin F 2 , and N τ -methylhistamine was observed in the AIA group than the ATA group. An increased excretion of LTE 4 and 9α, 11β-prostaglandin F 2 has been detected in a patient who suffered an asthma attack after percutaneous administration of nonsteroidal anti-inflammatory drugs. Conclusions: Considering that human lung mast cells are capable of producing LTC 4 , prostaglandin D 2 , and histamine, our present results support the concept that mast cells, at least, may participate in the development of aspirin-induced asthma.
Databáze: OpenAIRE
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