Understanding Retinal Microcircuitry: Then to Now

Autor: John E. Dowling, Frank S. Werblin
Rok vydání: 2017
Předmět:
Zdroj: Handbook of Brain Microcircuits
DOI: 10.1093/med/9780190636111.003.0022
Popis: This chapter focuses on the history of understanding retinal microcircuitry. To understand the microcircuitry underlying the responses of all ganglion cell types that exist in vertebrate retinas will require much work. We have a fairly good notion of how ON and OFF center ganglion cells are established by excitatory and inhibitory inputs in the outer plexiform layer (OPL) and inner plexiform layer (IPL), as well as how direction selection (DS) properties are imparted to ON-OFF ganglion cells in the IPL; but we have only fragmentary information regarding the microcircuitry of the other ganglion cell types. We do know where to look—along the various strata in the IPL. With electron microscope methods to determine synaptic circuitry and methods to record responses of single neurons in a circuit available, the microcircuitry of the strata in the IPL can be elucidated.
Databáze: OpenAIRE