Dexamethasone ester treatment alters insulin-like growth factor-I, its binding proteins and thyroid status in finishing calves
| Autor: | Veerle Darras, Arsène Burny, G. Room, Serge Massart, Lieve Vleurick, Isabelle Parmentier, Daniel Portetelle, Valérie Haezebroeck, Eddy Decuypere, Alberto Prandi, Robert Renaville, M. Tassinari, Carlo Bertozzi |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
biology medicine.medical_treatment Growth factor Deiodinase Thyroid Hypothalamic–pituitary–thyroid axis Enzyme assay Insulin-like growth factor Endocrinology medicine.anatomical_structure Food Animals Internal medicine medicine biology.protein Animal Science and Zoology Dexamethasone Hormone medicine.drug |
| Zdroj: | Canadian Journal of Animal Science. 80:329-335 |
| ISSN: | 1918-1825 0008-3984 |
| Popis: | To improve carcass quality in finishing calves, some breeders use preparations containing corticoids alone or in association with other growth promoters. We have investigated the effects of dexamethasone treatment on insulin-like growth factor-I (IGF-I), IGF-binding proteins (IGFBP-2 and 3) and thyroid hormones (T3, T4, free T4). Limousine male calves were allocated to a control group (C) (n = 18) and a group (n = 18) that received dexamethasone esters (DEX). Blood and hepatic tissue samples were collected at slaughtering. Thyroid hormones and IGF-I plasma levels were measured by RIA and IGFBPs were evaluated by immunoblotting. Hepatic type I 5′deiodinase (5′D-I) activity was determined by enzyme assay and hepatic expression of mRNA for GH receptor, IGF-I, IGFBP-2, IGFBP-3 and type I deiodinase (D-I) was evaluated by dot blot analysis. Plasma IGF-I and IGFBP-3 levels were reduced by the DEX treatment (P 3 plasma level was higher in DEX animals (P |
| Databáze: | OpenAIRE |
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