The Spectrum of IgE-Mediated Acute Allergic Reactions to Cow's Milk in Children as Determined by Skin Testing with Cow's Milk Protein Hydrolysate Formulas

Autor:	Margaret W. Keefe, Nick Harris, Robert H. Schwartz, Steven A. Witherly
Rok vydání:	1989
Předmět:	Pulmonary and Respiratory Medicine biology business.industry Skin test Immunoglobulin E medicine.disease Group B Hydrolysate Ige mediated Cow's milk protein Casein Pediatrics Perinatology and Child Health biology.protein Immunology and Allergy Medicine Food science business Asthma
Zdroj:	Pediatric Asthma, Allergy & Immunology. 3:207-215
ISSN:	1557-7767 0883-1874
DOI:	10.1089/pai.1989.3.207
Popis:	Children with adverse reactions to cow's milk (CM) often are given infant formulas containing CM proteins (casein or whey proteins) modified by hydrolysis to reduce their allergenicity. Recently, a few reports of acute allergic reactions to these CM hydrolysates have appeared in the medical literature. Therefore, between January 1, 1989, and August 31, 1989, we studied 26 children with a current history of recurrent acute respiratory (asthma, 19/26) or cutaneous (26/26, urticaria) reactions to CM. They were prick skintested with CM, two whey hydrolysates (Good Start HA and Alfare), and two casein hydrolysates (Nutramigen and Alimentum). Serum-specific IgE (sIgE IU/ml) to CM was measured by the 3M Fast method. Unexpectedly, high frequencies of positive prick tests were found to the whey (69%) and to the casein (38%) hydrolysate products. On the basis of skin test positivity, patients could be separated into three groups: group A (n = 8, positive only to CM), group B (n = 8, positive to CM and whey hydrolys...
Databáze:	OpenAIRE
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