Micellar nanocontainers based on cationic surfactants with a pyrrolidinium head group for increasing drug bioavailability

Autor:	Elmira A. Vasilieva, L. Ya. Zakharova, Gulnara A. Gaynanova, L. A. Vasileva, Farida G. Valeeva, D. A. Kuznetsova, Svetlana S. Lukashenko
Rok vydání:	2021
Předmět:	chemistry.chemical_classification Chemistry Cationic polymerization General Chemistry Medicinal chemistry Bioavailability Homologous series chemistry.chemical_compound Meloxicam Pulmonary surfactant medicine Moiety heterocyclic compounds Quercetin Alkyl medicine.drug
Zdroj:	Russian Chemical Bulletin. 70:1341-1348
ISSN:	1573-9171 1066-5285
Popis:	A homologous series of cationic surfactants with a pyrrolidinium head group containing a hydroxyethyl moiety was studied for the solubilization of nonsteroidal anti-inflammatory drugs, indomethacin and meloxicam, and the antioxidant quercetin. For indomethacin, the solubilization capacity linearly increases with increasing number of carbon atoms in the alkyl chain. In the case of quercetin and meloxicam, the solubilization capacity passes through a maximum for the hexadecyl derivative. The possibility of solubilization by premicellar surfactant aggregates was shown for indomethacin and meloxicam.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2bc24d00add32f7de3e0e049c82bce07 https://doi.org/10.1007/s11172-021-3221-4 Zobrazit plný text záznamu Full text from SpringerLink