Global Metabolomic Profiling of Host Red Blood Cells Infected with Babesia divergens Reveals Novel Antiparasitic Target Pathways

Autor:	Divya Beri, Manpreet Singh, Marilis Rodriguez, Naman Goyal, Giselle Rasquinha, Yunfeng Liu, Xiuli An, Karina Yazdanbakhsh, Cheryl A. Lobo
Rok vydání:	2023
Předmět:	Microbiology (medical) Infectious Diseases General Immunology and Microbiology Ecology Physiology Genetics Cell Biology
Zdroj:	Microbiology Spectrum. 11
ISSN:	2165-0497
Popis:	Human babesiosis is caused by apicomplexan parasites of the Babesia genus and is associated with transfusion-transmitted illness and relapsing disease in immunosuppressed populations. Through its continuous cycles of invasion, proliferation, and egress, B. divergens radically changes the metabolic environment of the host red blood cell, allowing us opportunities to study potential chemical vulnerabilities that can be targeted by drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2bb6ea12d933eac716285fe049ecf81c https://doi.org/10.1128/spectrum.04688-22 Zobrazit plný text záznamu