Mechanisms for the construction and developmental control of heterochromatin formation and imprinted chromosome domains

Autor:	Marilyn Bremer, Kenneth D. Tartof
Rok vydání:	1990
Předmět:	Genetics Chromosome (genetic algorithm) Mechanism (biology) Heterochromatin Heterochromatin formation Position-effect variegation Biology Genomic imprinting Control (linguistics) Molecular Biology Gene Developmental Biology
Zdroj:	Development. 108:35-45
ISSN:	1477-9129 0950-1991
DOI:	10.1242/dev.108.supplement.35
Popis:	The study of variegating position effects in Drosophila provides a model system to explore the mechanism and material basis for the construction and developmental control of heterochromatin domains and the imprinted genomic structures that they may create. The results of our experiments in this regard have implications for a diverse assortment of long-range chromosome phenomena related to gene and chromosome inactivation. Specifically, as a consequence of our studies on position effect variegation, we propose a simple mechanism of X-chromosome inactivation, suggest a purpose for genomic imprinting, and postulate a general means for regulating the time in development at which certain genes become heterochromatically repressed.
Databáze:	OpenAIRE
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