Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8
| Autor: | Reiko Ishimaru, Satoshi Chinaka, Takaya Murakami, Yoshiaki Iwamuro |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.drug_class
business.industry 010401 analytical chemistry Biochemistry (medical) Pharmacology toxicology Muscle relaxant Toxicology 01 natural sciences Sugammadex 0104 chemical sciences Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Liquid chromatography–mass spectrometry Anesthesia medicine 030216 legal & forensic medicine Rocuronium business medicine.drug |
| Zdroj: | Forensic Toxicology. 37:250-253 |
| ISSN: | 1860-8973 1860-8965 |
| Popis: | This case report describes the purposeful forensic detection of both the muscle relaxant rocuronium and the reversal agent sugammadex in the blood of a patient who died 8 days after surgery. The two compounds were analyzed by liquid chromatography/mass spectrometry (LC/MS). The molar concentrations of the two compounds were almost the same, indicating that rocuronium had lost its muscle relaxant effect, because rocuronium and sugammadex formed a 1:1 complex in the blood due to their high affinities. When a muscle relaxant is detected in a forensic sample, the presence of its reversal agent should also be investigated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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