Simple and feasible design of a polymeric nanoparticle for efficient anticancer drug delivery
| Autor: | Yue Zhao, Rui Zhong, Ming Yang, Zhenlin Zhou, Yongqiang Fu, Lina He |
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| Rok vydání: | 2021 |
| Předmět: |
Drug
Chemistry General Chemical Engineering media_common.quotation_subject Chain transfer 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Biochemistry Combinatorial chemistry Micelle Industrial and Manufacturing Engineering 0104 chemical sciences chemistry.chemical_compound Polymerization In vivo Drug delivery Amphiphile Materials Chemistry Phenylboronic acid 0210 nano-technology media_common |
| Zdroj: | Chemical Papers. 75:4035-4044 |
| ISSN: | 1336-9075 2585-7290 |
| DOI: | 10.1007/s11696-021-01589-9 |
| Popis: | In this paper, we present a simple and feasible drug self-assembled delivery system with pH responsiveness and targeting function for cancer therapy. The drug delivery system is composed of an anticancer drug and an amphiphilic random copolymer based on phenylboronic acid, galactose, and polyethylene glycol monomethyl ether acrylate molecules and achieved through reversible addition–fragmentation chain transfer polymerization. The micelles present targeting function by introducing galactose molecules and show pH sensitivity on the basis of the interactions between phenylboronic acid and galactose molecules. Particle size, transmission electron microscopy, and drug release assays show the pH-responsive behavior of micelles at pH 6.0. Cellular uptake assay demonstrates that micelles can internalize HepG2 cells via receptor-mediated interaction. In addition, the drug-loaded micelles can considerably inhibit cancer cell proliferation as indicated by in vivo antitumor assay. The synthesized micelles may facilitate the development of valid drug delivery systems for cancer therapy. |
| Databáze: | OpenAIRE |
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