Capabilities of laser technology for manufacturing diagnostic peptide matrices with maximal density
| Autor: | E. N. Sobol, A. Nesterov-Müller, O. I. Baum, E. M. Shcherbakov |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Materials science business.industry Statistical and Nonlinear Physics Polymer Substrate (electronics) Laser Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials law.invention Wavelength Thermal conductivity chemistry law Optoelectronics Deposition (phase transition) Irradiation Electrical and Electronic Engineering business Layer (electronics) |
| Zdroj: | Quantum Electronics. 46:173-178 |
| ISSN: | 1468-4799 1063-7818 |
| DOI: | 10.1070/qel15930 |
| Popis: | The process of manufacturing a matrix-gel biochip is modelled by means of laser fused deposition of a layer of polymer microparticles, containing a sensitive peptide element, onto a glass substrate. The limits of acceptable ranges and the optimal values of laser parameters, at which the melting of the polymer coating occurs without damaging the sensitive elements of the biochip, are theoretically determined. The results of the experiments on laser fused deposition of a layer of microparticles having the size 3 – 4 μm confirm the conservation of the functions of the biological complexes at optimal irradiation regimes. The parameters of the laser impact affecting the possible minimal separation between the zones of laser fused deposition are investigated. The essential role of heat conductivity and thermoplasticity of the polymer in increasing the size of the melted droplet is demonstrated. Using the laser radiation with the wavelength 532 nm focused into a spot with the diameter 6 μm (the laser pulse duration being 10 ms) the laser fused deposition density of 110000 spots per 1 cm2 is achieved. The maximal estimated density of laser fused deposition for the studied system amounts to 250000 spots per 1 cm2. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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