Silver-based wound dressings reduce bacterial burden and promote wound healing
| Autor: | Jui Hsiang Lin, Yu Hsin Lin, Tse Hao Ko, Wei Shan Hsu, Wan Yu Chung |
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| Rok vydání: | 2015 |
| Předmět: |
Sodium carboxymethylcellulose
medicine.medical_specialty integumentary system business.industry Rat model 02 engineering and technology Dermatology Bacterial growth 021001 nanoscience & nanotechnology Microbiology Surgery 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine In vivo Medicine 0210 nano-technology Early phase business Wound healing |
| Zdroj: | International Wound Journal. 13:505-511 |
| ISSN: | 1742-4801 |
| DOI: | 10.1111/iwj.12467 |
| Popis: | Various types of wound dressings have been designed for different purposes and functions. Controlling bacterial burden in a wound during the early phase is important for successful wound repair. Once bacterial burden is under control, the active promotion of wound healing is another important factor for efficient wound healing. This study investigated the potential of three silver-containing dressings, namely KoCarbonAg(®) , Aquacel(®) Ag and Acticoat 7, in reducing bacterial survival and promoting wound healing. The ability of these dressings to block the entry of bacteria from external environment and retain intrinsic bacteria was studied in vitro. In addition, the study used a rat model to compare the healing efficiencies of the three dressings and investigate the quantity of collagen synthesis in vivo. In vitro results indicated that the silver-containing dressings prevented bacterial growth in wounds by blocking the entry of external bacteria and by retaining the bacteria in the dressing. In vivo study indicated that reduction in bacterial burden accelerated wound healing. Wounds treated by the silver-containing dressings showed better healing than those treated with gauze. Moreover, KoCarbonAg(®) further accelerated wound healing by promoting collagen synthesis and arrangement. |
| Databáze: | OpenAIRE |
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