Preparation and properties of liposomes coated with N-acylated low-molecular-weight chitosan
| Autor: | Tamara F. Solov'eva, V. I. Gorbach, G. A. Naberezhnykh, S. Yu. Bratskaya |
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| Rok vydání: | 2011 |
| Předmět: |
Liposome
Low molecular weight chitosan technology industry and agriculture macromolecular substances Plant Science General Chemistry equipment and supplies General Biochemistry Genetics and Molecular Biology Neutralization carbohydrates (lipids) Chitosan chemistry.chemical_compound chemistry Amphiphile Nuclear chemistry |
| Zdroj: | Chemistry of Natural Compounds. 46:852-856 |
| ISSN: | 1573-8388 0009-3130 |
| DOI: | 10.1007/s10600-011-9767-x |
| Popis: | Amphiphilic low-molecular-weight chitosan N-acylated with 3-hydroxytetradecanoic acid was synthesized. It was shown that addition of the acylated chitosan changes the surface potential and size of negatively charged liposomal particles, the magnitudes of which depend on the chitosan concentration. Charge neutralization and aggregation of the liposomes occurs at low chitosan concentration. Increasing its concentration produces positive charge on the surface of the liposomes and decreases their size. This increases the stability of the liposomal particles in solution. Liposomes coated with chitosan may be of interest as carriers for genes, vaccines, and drugs. |
| Databáze: | OpenAIRE |
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