Exercise and health-related fitness predictors of chemotherapy completion in breast cancer patients: pooled analysis of two multicenter trials
| Autor: | John R. Mackey, Dong-Woo Kang, Ki-Yong An, Donald C. McKenzie, Karen A. Gelmon, Stephanie M Ntoukas, Fernanda Z. Arthuso, Andria R. Morielli, Kerry S. Courneya, Christine M. Friedenreich |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty business.industry Strength training Physical fitness Physical strength medicine.disease Logistic regression 03 medical and health sciences Regimen 030104 developmental biology 0302 clinical medicine Breast cancer Oncology Tolerability 030220 oncology & carcinogenesis Internal medicine medicine business Cardiovascular fitness |
| Zdroj: | Breast Cancer Research and Treatment. |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1007/s10549-021-06205-8 |
| Popis: | Achieving a higher chemotherapy completion rate is associated with better outcomes in breast cancer patients. We examined the role of exercise and health-related fitness variables in predicting chemotherapy completion in early stage breast cancer patients. We pooled data from two large, multicenter, exercise trials that obtained baseline (pre-chemotherapy) measures of exercise and health-related fitness in 543 breast cancer patients initiating adjuvant chemotherapy. Assessments included body composition, cardiovascular fitness, muscular strength, patient-reported physical functioning, and self-reported exercise behavior. Chemotherapy completion was assessed as the average relative dose intensity (RDI) for the originally planned regimen. We used logistic regression analyses with a two-sided p value of |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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