Sequential Conia-ene-type cyclization and Negishi coupling by cooperative functions of B(C6F5)3, ZnI2, Pd(PPh3)4 and an amine

Autor:	Min Cao, Jason Genova, Masayuki Wasa, Ahmet Yesilcimen, Soumil Prasad, Tanner Myers
Rok vydání:	2020
Předmět:	chemistry.chemical_classification Negishi coupling Aryl Organic Chemistry Alkyne Biochemistry Medicinal chemistry Catalysis chemistry.chemical_compound chemistry Moiety Amine gas treating Lewis acids and bases Physical and Theoretical Chemistry Ene reaction
Zdroj:	Organic & Biomolecular Chemistry. 18:7090-7093
ISSN:	1477-0539 1477-0520
DOI:	10.1039/d0ob01678k
Popis:	We disclose a method for sequential Conia-ene-type cyclization/Negishi coupling for the union of alkynyl ketones and aryl iodides. This process is promoted through cooperative actions of Lewis acidic B(C6F5)3, ZnI2, Pd-based complex, and a Bronsted basic amine. The three Lewis acid catalysts with potential overlapping functions play their independent roles as activators of carbonyl group, alkyne moiety, and alkenyl zinc intermediate, respectively. A variety of 1,2,3-substituted cyclopentenes can be synthesized with high efficiency.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2b7db1635263210e6bf4372908a90655 https://doi.org/10.1039/d0ob01678k Zobrazit plný text záznamu