Liposome-Mediated Delivery of Photosensitizers: Localization of Zinc (11)-Phthalocyanine within Implanted Tumors after Intravenous Administration

Autor:	W. G. Love, Giulio Jori, S. Duk, Roberta Biolo, P. W. Taylor
Rok vydání:	1996
Předmět:	Muscle tissue Liposome Necrosis Chemistry Melanoma General Medicine medicine.disease Biochemistry medicine.anatomical_structure Immunology Fluorescence microscope Carcinoma medicine Cancer research Photosensitizer Physical and Theoretical Chemistry medicine.symptom Drug carrier neoplasms
Zdroj:	Photochemistry and Photobiology. 63:656-661
ISSN:	1751-1097 0031-8655
DOI:	10.1111/j.1751-1097.1996.tb05670.x
Popis:	CGP55847, liposomal zinc(II)-phthalocyanine (Zn-Pc), was administered by the intravenous route to Swiss mice bearing intramuscularly implanted Ehrlich carcinomas or to C57/BL6 mice bearing subcutaneously implanted B16 melanomas. Tumors were removed 3 h or 24 h after dosing the intratumoral distribution determined by fluorescence microscopy. Localization of the photosensitizer occurred more rapidly in the Ehrlich carcinoma than in the B16 melanoma; this difference in photosensitizer uptake may be related to a higher degree of vascularization of the carcinoma. The photosensitizer was found in association with blood vessels at 3 h but not 24 h after dosing and appeared to have a greater affinity for areas of tissue necrosis within the tumor compared to viable tumor tissue. Little or no Zn-Pc was detected in the muscle tissue invaded by the Ehrlich carcinoma and was associated with the membranes and the cytosol, but not the nucleus, of cells in both tumors.
Databáze:	OpenAIRE
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