| Autor: |
D. H. Calam, A. Rozanski, B. Silver, G. Raiola, Jos Hoogmartens, J. Paesen, J. H. Mc. B. Miller |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Journal of Liquid Chromatography. 16:1529-1544 |
| ISSN: |
0148-3919 |
| DOI: |
10.1080/10826079308020971 |
| Popis: |
A previously established method for analysis of erythromycin and related substances by liquid chromatography using a wide-pore poly(styrene-divinylbenzene) stationary phase was examined in a multicentre study involving 6 laboratories and a total of 7 columns. Three erythromycin samples were analysed. The main component and the impurities were determined. An analysis of variance treating each column as a different laboratory, showed absence of consistent laboratory bias and of laboratory-sample interaction. Estimates for the repeata-bility and reproducibility of the method, expressed as relative standard deviation (RSD) of the result of the determination of erythromycin A, were calculated to be 1.1 % and 1.3 % respectively. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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