Activation of reverse Na+-Ca2+ exchanger by skeletal Na+ channel isoform increases excitation-contraction coupling efficiency in rabbit cardiomyocytes

Autor:	Natalia S. Torres
Rok vydání:	2021
Předmět:	Coupling (electronics) Cardiac excitation-contraction coupling Gene isoform Physiology Chemistry Physiology (medical) Excitation–contraction coupling Biophysics Ventricular myocytes Cardiology and Cardiovascular Medicine
Zdroj:	American Journal of Physiology-Heart and Circulatory Physiology. 320:H593-H603
ISSN:	1522-1539 0363-6135
DOI:	10.1152/ajpheart.00545.2020
Popis:	A number of studies suggest that the Na+-Ca2+ exchanger (NCX) activated by Na+ currents is involved in the process of excitation-contraction (EC) coupling in cardiac ventricular myocytes. Although insufficient to trigger sarcoplasmic Ca2+ release alone, the Ca2+ entering through reverse NCX during an action potential can prime the dyadic cleft and increase the Ca2+ current coupling fidelity. Using specific Na+ inhibitors in this study, we show that in rabbit ventricular cells the skeletal Na+ channel isoform (Nav1.4) is the main isoform responsible for this priming. Our study provides insights into a mechanism that may have an increased relevance where EC coupling is remodeled.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2b79c5a59d22a9cc6541278307f0f159 https://doi.org/10.1152/ajpheart.00545.2020 Zobrazit plný text záznamu