| Autor: | J. L. Langowski, L. Owen-Schaub, Esther A. Guzmán |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
Cancer Research Programmed cell death Epidermis (botany) Biochemistry (medical) Clinical Biochemistry Pharmaceutical Science Cell Biology Biology medicine.disease medicine.disease_cause Fas ligand Apoptosis Immunology medicine Tumor necrosis factor alpha Skin cancer Receptor Carcinogenesis |
| Zdroj: | APOPTOSIS. 8:315-325 |
| ISSN: | 1360-8185 |
| Popis: | Apoptosis plays a critical role in the development and progression of ultraviolet-induced skin cancers. In particular, Fas and Fas ligand (FasL) interactions are known to control the development of “sunburn cells” or apoptotic keratinocytes in the UV-exposed epidermis. In the absence of functional Fas/FasL signaling, UV-induced apoptosis is diminished and mutations rapidly accumulate. UV-induced suppression of host immunity, a process regulating skin cancer outgrowth, is also controlled through Fas/FasL interactions. Other death receptors, such as the receptor for tumor necrosis factor, may also contribute to UV-induced carcinogenesis and progression. Understanding the involvement of cell death in cancers caused by exposure to sunlight may provide novel approaches for prevention and therapy of these ever-increasing malignancies. |
| Databáze: | OpenAIRE |
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