Role of tranexamic acid in blood loss control and blood transfusion management of patients undergoing multilevel spine surgery
| Autor: | Yibo Zhao, Wen-Xiao Xu, Jinglong Yan, Chunyang Xi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Blood transfusion
business.industry medicine.medical_treatment Case-control study General Medicine Cochrane Library law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law 030220 oncology & carcinogenesis Relative risk Anesthesia Meta-analysis Medicine 030212 general & internal medicine business Tranexamic acid Cohort study medicine.drug |
| Zdroj: | Medicine. 100:e24678 |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | BACKGROUND This study aimed to explore the role of tranexamic acid (TXA) in blood loss control and blood transfusion management of patients undergoing multilevel spine surgery. METHODS In this meta-analysis, a comprehensive search of literatures was performed from PubMed, Embase, Cochrane Library, and Web of Science from inception to June 23rd, 2020. Weighed mean difference (WMD) was used as the effect size for measurement data, and risk ratio for enumeration data. Publication bias was assessed by Begg test. RESULTS Totally 23 studies (11 randomized controlled trials and 12 cohort studies) involving 1621 participants were enrolled in this meta-analysis. The results showed that the administration of TXA can significantly decrease the intraoperative [WMD: -215.655, 95%CI: (-307.462, -123.847), P |
| Databáze: | OpenAIRE |
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