The effects of L-DOPA on cytochemical indices of oxidative metabolism in the brains of rats with different levels of motor activity

Autor: V. I. Rakhmanova, A. V. Sergutina
Rok vydání: 2013
Předmět:
Zdroj: Neurochemical Journal. 7:291-295
ISSN: 1819-7132
1819-7124
DOI: 10.1134/s1819712413030124
Popis: We studied the brains of Wistar rats with high and low levels of motor activity in the “open field” test under normal conditions and after prolonged L-DOPA administration and its withdrawal. We performed a cytochemical study of glucose-6-phosphate dehydrogenase activity in neurons of layers III and V of the sensorimotor cortex, caudate nucleus, nucleus accumbens, and hippocampus (CA3 field). We compared the alterations of the activity of glucose-6-phosphate dehydrogenase with changes in the activity of glutamate dehydrogenase under the same conditions. We found an increase in the glucose-6-phosphate dehydrogenase and glutamate dehydrogenase activities in the striatum of rats with a high level of motor activities after L-DOPA administration. The alterations of the glucose-6-phosphate dehydrogenase and glutamate dehydrogenase activities were different in the sensorimotor cortex. Cytochemical indices in the brains of these rats recovered to a normal state after L-DOPA withdrawal. In rats with a low level of motor activity, L-DOPA administration increased glucose-6-phosphate dehydrogenase activity in the striatum (nucleus accumbens). In these rats, glutamate dehydrogenase activity decreased in the striatum and increased in the hippocampus. L-DOPA withdrawal resulted in an increase in the glucose-6-phosphate dehydrogenase activity in layer V of the sensorimotor cortex and a decrease in the glutamate dehydrogenase activity in the caudate nucleus. Thus, it was shown that the response of the oxidative metabolism of the brain to the activation of the dopaminergic system depends on the traits of a animal’s behavior, in particular, its motor activity.
Databáze: OpenAIRE
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