NATURAL HISTORY OF MITRAL ANNULUS CALCIFICATION AND CALCIFIC MITRAL VALVE DISEASE

Autor: Kathryn J. Ascah, T. Mesana, David Messika-Zeitoun, Kwan L. Chan, Thais Coutinho, Ian G. Burwash, Steven Promislow, N Willner, Luc M. Beauchesne, Branka Vulesevic
Rok vydání: 2021
Předmět:
Zdroj: Canadian Journal of Cardiology. 37:S76-S77
ISSN: 0828-282X
Popis: BACKGROUND Mitral annular calcification (MAC) is a common finding, but the natural history and risk for developing calcific mitral valve disease (CMVD) have been poorly defined. We sought to evaluate the progression rate of MAC and of the development of CMVD. METHODS AND RESULTS Patients with at least mild MAC and paired echocardiograms at least one year apart between 2005 and 2019 were included. Progression rates from mild/moderate MAC to severe MAC and to CMVD (defined as severe MAC and significant mitral stenosis and/or regurgitation) were assessed, along with potential associations with sex and aortic valve stenosis (AS) progression. A total of 11,605 patients (73±10 years, 51% male) with MAC (78% mild, 17% moderate, 5% severe) were included and had a follow up echocardiogram at 4.2±2.7 years. In patients with mild/moderate MAC on their initial echocardiogram, the incidence of severe MAC at 10 years was 33%. The incidence was higher in females than in males (41% vs. 24%, P CONCLUSION In this large patient cohort with MAC, progression to severe MAC is common and frequently results in CMVD. Female sex was associated with higher progression rates and an association between MAC and AS progression was observed. MAC and CMVD are expected to dramatically increase as the population ages and there is an urgent need to better understand the pathophysiology of MAC in order to develop effective preventative medical therapies.
Databáze: OpenAIRE
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