PolycyclicN-heterocyclic compounds.XLV.Synthesis of 4-substituted 5,6-dihydrobenzo[h]quinazolines and 6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidines and their inhibitory activity on platelet aggregation

Autor:	Taiji Nakayama, Hiromi Ohtomo, Yuhki Sekiya, Hideko Fujiwara, Takashi Hirota, Kenji Sasaki
Rok vydání:	1993
Předmět:	chemistry.chemical_classification Platelet aggregation Chemistry medicine.drug_class Carboxylic acid Organic Chemistry Biological activity Carboxamide Inhibitory postsynaptic potential Medicinal chemistry chemistry.chemical_compound Amide medicine Nitrite
Zdroj:	Journal of Heterocyclic Chemistry. 30:993-995
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570300426
Popis:	The synthesis of 4-substituted 5,6-dihydrobenzo[h]quinazolines and 6,7-dihydro-5H-benzo[6,7]cyclohepta-[1,2-d]pyrimidines with substituents which are an electron-attracting group such as a nitrite, an amide, a thione, or a carboxyl group is described. Their inhibitory activity against collagen-induced platelet aggregation was also investigated.
Databáze:	OpenAIRE
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