A case of synchronous high‐grade cervical intraepithelial neoplasia and metastatic squamous cell carcinomas of unknown primary in rectum
| Autor: | Takeshi Obata, Junpei Iwadare, Syunsuke Orisaka, Yasunari Mizumoto, Hiroshi Fujiwara, Mitsuhiro Nakamura |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry Cell Obstetrics and Gynecology Rectum Magnetic resonance imaging Cervical intraepithelial neoplasia medicine.disease female genital diseases and pregnancy complications stomatognathic diseases 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Transrectal biopsy 030220 oncology & carcinogenesis Biopsy High Grade Cervical Intraepithelial Neoplasia medicine skin and connective tissue diseases business neoplasms Pathological |
| Zdroj: | Journal of Obstetrics and Gynaecology Research. 47:2555-2559 |
| ISSN: | 1447-0756 1341-8076 |
| DOI: | 10.1111/jog.14798 |
| Popis: | We report a case of synchronous high-grade cervical intraepithelial neoplasia (CIN) and metastatic squamous cell carcinomas (SCCs) of unknown primary in the rectum. A 74-year-old woman was diagnosed with CIN3 by biopsy of the uterine cervix. Magnetic resonance imaging showed two masses in the outer rectal wall. They were diagnosed as SCCs by transrectal biopsy from one mass. On surgical treatment, CIN3 and SCCs in the rectum were identified, respectively. Pathological analysis revealed that SCCs were observed in serosa of the rectum, not mucosa, indicating that these tumors were metastatic SCCs. Gene analysis showed HPV31-positive and TP53 mutation in CIN3, and HPV16-positive in rectal SCCs. Pretreatment examination did not detect the primary site of metastatic SCCs in the rectum. We diagnosed the patient with synchronous CIN3 and metastatic SCCs of unknown primary in the rectum. In this case, gene analysis was useful to clarify the relationship between CIN3 and SCCs. |
| Databáze: | OpenAIRE |
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