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Introduction PE complicates 5–8% of pregnancies and is the leading cause of maternal death-about 60 000 women die from it every year around the world. It should be noted that to date, early (up to 34 weeks) and late (after 34 weeks) PE are seen as two completely separate units, rather than as different clinical forms of the same disease. Objective To study risk factors in women, whose pregnancy was complicated by severe preeclampsia with early and late debut. Methods A retrospective cohort study of 254 histories of pregnant women operated on for severe PE. Results and its discussion The early onset of preeclampsia was in women with multiple pregnancies (4.5%), with genetic thrombophilia (6.4%). Heavy PE with late onset was observed in obese women (23.2%). Primiparity, chronic arterial hypertension, kidney disease are the most common risk factors for severe PE, but do not have significant differences in women with early and late PE. In both early and late PE, the leading position was occupied by chronic arterial hypertension (33%). In contrast to early PE in obese women with late PE, 13.5% occurred. At early PE – disturbances of system of a hemostasis (genetic trombophilia) it is marked in 6,4% of observations. In 24.1% of cases, the somatic history was not burdened. The frequency of occurrence of PE in previous pregnancies did not have significant differences between the groups with early and late PE (11.2% and 12.6%, respectively). In the group of pregnant women due to IVF-the frequency of severe PE was 8.3%. Of these, 6.7% fell to early PE, 1.6% to late PE. In case of multiple pregnancies, the rate of development of severe PE reached 12.2%. Early debut up to 34 weeks is marked in 8,7%, late-3,5%. |
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