| Autor: |
Jacqueline Besson, Jacques Epelbaum, W.H. Rotsztejn, Lucia Tapia-Aranciba |
| Rok vydání: |
1979 |
| Předmět: |
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| Zdroj: |
European Journal of Pharmacology. 58:493-495 |
| ISSN: |
0014-2999 |
| DOI: |
10.1016/0014-2999(79)90323-6 |
| Popis: |
The effect of vasoactive intestinal peptide (VIP) was studied on the release of somatostatin (SRIF) from slices of several regions of the rat brain in vitro. VIP induced a dose-dependent inhibition of SRIF release from mediobasal hypothalamic slices but did not interfere with SRIF release from preoptic area, amygdala or cortex. VIP Inhibition had an apparent affinity: Kd = 6.8 ± 3.9 × 10−11 M. Secretin has a similar effect but at 600-fold higher concentrations (Kd secretin = 4.2 ± 0.6 × 10−8 M). Glucagon was ineffective in concentrations ranging from 10−10 M to 10−7 M. The data are consistent with a role of VIP in the hypothalamic control of growth hormone secretion. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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