Metabolism of O-benzoylthiamine in animal body

Autor:	Yoshinori Itokawa, Kikuko Inoue
Rok vydání:	1973
Předmět:	chemistry.chemical_classification food and beverages Urine Metabolism Pharmacology Biology Biochemistry chemistry.chemical_compound O-benzoylthiamine Enzyme chemistry Toxicity Thiamine Animal body human activities Benzoic acid
Zdroj:	Biochemical Medicine. 8:450-463
ISSN:	0006-2944
DOI:	10.1016/0006-2944(73)90049-5
Popis:	Experiments were carried out to elucidate the metabolism of O-benzoylthiamine in animals. 1. 1. Toxicity of O-benzoylthiamine was much higher than thiamine or benzoic acid, components of O-benzoylthiamine. 2. 2. O-Benzoylthiamine was excreted in the urine not only after administration of O-benzoylthiamine but also after administration of other benzoyl containing thiamine derivatives. 3. 3. Enzymes in the rat liver convert O-benzoylthiamine to thiamine thiazolone while enzymes in other tissues converts it to thiamine. 4. 4. Biological thiamine activity of O-benzoylthiamine was lower than that of thiamine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2b542d4c1be9f299ca99d4ab5c1b5dbe https://doi.org/10.1016/0006-2944(73)90049-5 Zobrazit plný text záznamu