External heating of stents by radio waves

Autor: Nicolas A.F. Chronos, Keith Robinson, Wolfgang Daum, Adam B. Levitt
Rok vydání: 2003
Předmět:
Zdroj: Cardiovascular Radiation Medicine. 4:133-138
ISSN: 1522-1865
DOI: 10.1016/s1522-1865(03)00166-5
Popis: Purpose: This experiment was designed to assess the feasibility of radio frequency energy delivered by a prototype radio frequency generator inductive heating device (REVAX) positioned external to the body, for transient heating of stents after arterial implant. Methods and Materials: Twenty-one New Zealand White rabbits underwent stenting of their infrarenal aorta. Nine rabbits were stented and immediately placed in the REVAX for external stent heating with internal temperature probes in place. Twelve rabbits were stented and 3 days later either heated or placed in the generator as a sham for 20 min. The animals were terminated 28 days later. Results: The REVAX was able to heat the aortic stents in a controlled fashion; in Phase II experiments, the stent temperature was raised to 42 °C for 20 min. In Phase I mild necrosis was noted at the stent struts. In Phase II, necrosis and mineralization of the media was seen at the stent struts, and evidence of neointimal suppression was observed. Conclusion: This study demonstrated that external heating of stents in a blood vessel in a live animal via radio frequency energy is feasible. Further studies will be needed to assess whether any specific heating regimen might inhibit fibrocellular neointimal hyperplasia.
Databáze: OpenAIRE
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