| Popis: |
The 5-HT3 receptor (5-HT3R) is a ligand-gated ion channel gated by the neurotransmitter serotonin (5-HT) and belonging to the superfamily of ligand-gated ion channels, a group that includes nicotinic acetylcholine (ACh), GABA, and glycine receptor channels (MARiCQ et al. 1991). The activation of the 5-HT3R opens a cationic ion channel that depolarizes the membrane, thereby activating a rapid excitatory response in a variety of central and peripheral nervous system (CNS and PNS) preparations. Thus the 5-HT3R is unique from the other classes of 5-HT receptors which all couple to GTP binding proteins. |
