Transformation of 3-methylpyridine into nicotinic acid by the yeast S. cerevisiae

Autor:	N. Zh. Sagdiev, A. M. Kerbalaeva, T. G. Gulyamova, E. S. Sadykov, K. V. Lobanova
Rok vydání:	2006
Předmět:	chemistry.chemical_classification Nicotinamide Chemistry Stereochemistry 3-Methylpyridine Plant Science General Chemistry General Biochemistry Genetics and Molecular Biology Yeast chemistry.chemical_compound Transformation (genetics) Enzyme Nicotinic agonist Biochemistry Pyridine NAD+ kinase
Zdroj:	Chemistry of Natural Compounds. 42:212-215
ISSN:	1573-8388 0009-3130
DOI:	10.1007/s10600-006-0081-y
Popis:	It has been shown that the yeast S. cerevisiae has the ability to synthesize nicotinic acid and NAD from 3-methylpyridine. Fractionation of intracellular yeast proteins established that the fraction of molecular weight 65–90 kDa had the highest activity for transformation of pyridine derivatives into nicotinate. HPLC showed that, in addition to nicotinic acid, nicotinamide was also present in the intermediates during transformation of 3-methylpyridine. The results were consistent with the presence in yeast cells of an enzymatic system that transforms 3-methylpyridine into vitamin PP.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2b410f7fb05678db7719495081859ff1 https://doi.org/10.1007/s10600-006-0081-y Zobrazit plný text záznamu Plný text ve formátu PDF