Diastereotopic selectivity at prochiral carbon centers. A stereodivergent synthesis of the talaromycins

Autor:	Stuart L. Schreiber, Toby J. Sommer, Kunio Satake
Rok vydání:	1985
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Drug Discovery Acetal chemistry.chemical_element Organic chemistry Talaromycin B Selectivity Biochemistry Acetonide Carbon
Zdroj:	Tetrahedron Letters. 26:17-20
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)98454-5
Popis:	The transformation of the acyclic precursor previously employed in the synthesis of talaromycin B to the stereoisomeric avian toxin talaromycin A is described. Diastereotopic selectivity at prochiral carbon centers in an acetonide migration and in a subsequent spiroketalization reaction provides the stereocontrol required for the synthesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2b3f1770f740c0cb519a038c7f1f8d91 https://doi.org/10.1016/s0040-4039(00)98454-5 Zobrazit plný text záznamu