Ammonium Chloride Promoted One-Pot, Three-Component Mannich Reaction: An Efficient Synthesis of β-Amino Ketones and β-Amino Esters
| Autor: | Rekha R. Joshi, Jay Z. Chandanshive, Pradip D. Lokhande |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Asian Journal of Chemistry. 34:3353-3360 |
| ISSN: | 0975-427X 0970-7077 |
| DOI: | 10.14233/ajchem.2022.23978 |
| Popis: | Ammonium chloride was found to efficiently reagent for the one pot-three component Mannich reaction between aromatic aldehyde, ketone and amine in ethanol at room temperature to furnish β-amino ketones in good to excellent yields. The said protocol was further applied for the direct synthesis of β-amino esters, which are important precursors for the synthesis of β-amino acids. This protocol is potentially applicable for the development of a clean and environment-friendly strategy for the synthesis of β-amino ketones and found applications in the synthesis of potent biologically active molecules due to its simple experimental conditions, inexpensive reagents and straight forward product isolation procedure. |
| Databáze: | OpenAIRE |
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