Cardiovascular effects of medorinone in ?-adrenoreceptor-blocked and non-blocked anesthetized dogs

Autor:	King C. Lee, Dorothy J. Fort, Douglas W. Hamel, Paul C. Canniff, Edward D. Pagani, Alan M. Ezrin, Paul J. Silver
Rok vydání:	1990
Předmět:	Cardiac output Mean arterial pressure medicine.medical_specialty business.industry Hemodynamics Preload Blood pressure Endocrinology Internal medicine Renal blood flow Drug Discovery Ventricular pressure Medicine Milrinone business medicine.drug
Zdroj:	Drug Development Research. 21:119-133
ISSN:	1098-2299 0272-4391
DOI:	10.1002/ddr.430210205
Popis:	The hemodynamic effects of the low Km cAMP peak III PDE inhibitor medorinone (0.01–0.3 mg/kg, i. v. ) were evaluated in anesthetized dogs in the presence and absence of β-adrenoreceptor blocked. Medorinone increased the peak derivative of left ventricular pressure (+ dP/dt) in non-blocked (all doses) and β-blocked dogs (≥0.03 mg/kg) (2,766±259 and 1,403±262 mm Hg/sec, respectice max. changes). Heart rate (HR) was increased by medorinone in non-blocked (≥0.1 mg/kg) and β-blocked dogs (≥0.03 mg/kg) (77.4±8.9 and 25.5±4.3 beats/min, respective max. changes). In non-blocked dogs only, medorinone (all doses) decreased left ventricular end-diastolic pressure (LVEDP) (7.7±1.7 mm Hg, max. change). Mean arterial pressure (MAP) was similarly decreased by medorinone (
Databáze:	OpenAIRE
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