Kidney histology in streptozotocin-induced diabetic male Wistar rats treated with combined extract of temulawak rhizome and belimbing wuluh fruit
| Autor: | Nining Ratningsih, Ema Purnama Sari, Kartiawati Alipin, Tia Setiawati, Desak Made Malini, Madihah Madihah |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Kidney
food.ingredient Necrosis Averrhoa bilimbi business.industry 05 social sciences 030206 dentistry Pharmacology medicine.disease Streptozotocin Rhizome Glibenclamide 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure food Diabetes mellitus 0502 economics and business medicine 050211 marketing medicine.symptom business Completely randomized design medicine.drug |
| Zdroj: | Nusantara Bioscience. 9:312-317 |
| ISSN: | 2087-3956 2087-3948 |
| DOI: | 10.13057/nusbiosci/n090312 |
| Popis: | Alipin K, Sari EP, Madihah, Setiawati T, Ratningsih N, Malini DM. 2017. Kidney histology in streptozotocin-induced diabetic male Wistar rats treated with combined extract of temulawak rhizome and belimbing wuluh fruit. Nusantara Bioscience 9: 312-317. Complications that are occurred in patients with Diabetes Mellitus usually followed by kidney damage. Temulawak (Curcuma xanthorrhiza Roxb.) and belimbing wuluh (Averrhoa bilimbi L.) were traditionally used to decrease blood glucose level. Thus, they were potential as antidiabetic drugs. This study aimed to evaluate the combination of ethanol extracts of temulawak rhizome and belimbing wuluh fruit in repairing kidney damage in diabetic male Wistar rats induced by streptozotocin (STZ). An experimental method using a completely randomized design that consist of seven treatments with three replications. Six treatment groups were injected intraperitoneally with a dose of 60 mg/kg BW STZ, and one group served as a control. The animals which have blood glucose level ≥200 mg/dl were stated as diabetic. Furthermore, the animals were treated orally with single extract i.e. temulawak 17.5 mg/kg BW or belimbing wuluh 750 mg/kg BW and combined extracts 383.75 or 767.5 mg/kg BW, as well as glibenclamide 0.45 mg/kg BW as reference, including diabetic rat as positive control and non-diabetic rat as negative control. The results showed that combine extract at dose of 383.75 mg/kg BW treatment repaired the kidney histology, i.e., glomerular diameter and Bowman space width, as well as significantly decreased the necrosis percentage of proximal tubular in diabetic rat compared with positive control group (p |
| Databáze: | OpenAIRE |
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