| Autor: |
G.C. Gerritsen, W.E. Dulin, M. G. Soret |
| Rok vydání: |
1973 |
| Předmět: |
|
| DOI: |
10.1016/b978-0-12-027362-1.50036-4 |
| Popis: |
Publisher Summary This chapter discusses microangiopathy in animals with spontaneous diabetes. The chapter describes a study designed to document and correlate the relationship between morphological changes and metabolic disorders. For this study, diabetic and nondiabetic Chinese hamsters were examined. A summary of fasting blood sugar and plasma insulin levels of the diabetic ketoacidotic Chinese hamsters and their matched controls is presented in the chapter. The diabetic animals had markedly elevated fasting blood sugar and normal levels of fasting plasma insulin. Kidneys from some of the diabetic hamsters showed a distinct thickening of the mesangial matrix. The lesion was rather subtle in others and did not allow the separation of diabetics from nondiabetics on this basis. The only constant alteration observed in the kidneys of all the diabetics was a variable deposition of PAS-positive material in the epithelium of some of the distal convoluted tubules close to their respective glomeruli. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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