In Vivo Effects of 5.3 MeV Alpha Particles from 210Po Mouse Testes: Comparison with Internal Auger Emitters

Autor:	D.V. Rao, V.R. Narra, G.F. Govelitz, V.K. Lanka, R.W. Howell, K.S.R. Sastry
Rok vydání:	1990
Předmět:	Radiation Radiological and Ultrasound Technology Public Health Environmental and Occupational Health Radiology Nuclear Medicine and imaging General Medicine
Zdroj:	Radiation Protection Dosimetry. 31:329-332
ISSN:	1742-3406 0144-8420
Popis:	Using spermatogenesis in the mouse testis as the experimental model, we have investigated the in vivo effects of 5.3 MeV a particles in the decay of 210Po localised in the organ. Spermatogonial cell killing and induction of abnormal shapes in epididymal sperm are the biological end points. The mean lethal dose (D37) to the organ at 37% survival of spermatogonia is 100 mGy, while a dose of 5 mGy doubles the fraction of abnormal sperm in the epididymis. In contrast to these findings with densely ionising a particles are our results for the sparsely ionising 477 keV photons from internal 7Be, with D37 = 670 mGy, and 250 mGy for a doubling of the abnormal sperm fraction. These results, and those obtained with several internal Auger emitters in the same model, are examined in terms of radionuclide localisation and radiation quality.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2b0a67d8995f61fd5913d05e8fccd1fd https://doi.org/10.1093/rpd/31.1-4.329 Zobrazit plný text záznamu