| Autor: | Robert C. DiLuccio, Munir A. Hussain, David Coffin-Beach, George Torosian, Eli Shefter, Arthur R. Hurwitz |
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| Rok vydání: | 1989 |
| Předmět: |
Pharmacology
Acrylate integumentary system Organic Chemistry Pharmaceutical Science respiratory system Polyvinyl alcohol eye diseases Dosage form Bioavailability chemistry.chemical_compound Crystallinity chemistry Phenylpropanolamine Hydrochloride Polymer chemistry medicine Molecular Medicine Pharmacology (medical) sense organs Methyl acrylate Phenylpropanolamine Biotechnology medicine.drug Nuclear chemistry |
| Zdroj: | Pharmaceutical Research. :844-847 |
| ISSN: | 0724-8741 |
| DOI: | 10.1023/a:1015900303534 |
| Popis: | Low crystalline and crystalline polyvinyl alcohol-methyl acrylate (PVA-MA) copolymers were examined, because of their excellent flow and compressibility properties, as matrices for sustained-release tablets using phenylpropanolamine hydrochloride (PPA.HCl) as a model drug. Crystallinity of the copolymer affected the release characteristics from the tablet. Tablets made with low-crystalline PVA-MA provided sustained release of PPA, both in vitro and in vivo in dogs. PPA absorption from the low-crystalline PVA-MA tablet formulation was biphasic. An initial rapid phase was followed by a second, slower absorption phase which continued over 16 hr. Plasma PPA concentrations then declined with a half-life roughly parallel to the oral immediate-release half-lives. Oral bioavailability from the low-crystalline PVA-MA tablet formulation was 78.8 +/- 3.9%. |
| Databáze: | OpenAIRE |
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