In vitro drug release study from hydroxyapatite-alumina composites
| Autor: | E. B. Duarte, Joelane Maria de Carvalho Teixeira, Suely Alves Silva, J. S. V. Alburquerque, Ricardo Emílio Ferreira Quevedo Nogueira |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
Biocompatibility Scanning electron microscope New materials Context (language use) 02 engineering and technology General Chemistry Mechanical resistance 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Controlled release 0104 chemical sciences Electronic Optical and Magnetic Materials Characterization (materials science) Biomaterials Materials Chemistry Ceramics and Composites Drug release Composite material 0210 nano-technology |
| Zdroj: | Journal of Sol-Gel Science and Technology. 89:521-530 |
| ISSN: | 1573-4846 0928-0707 |
| DOI: | 10.1007/s10971-018-4888-3 |
| Popis: | Modern technologies require new materials with an increasingly varied set of properties. In this context, biomaterials such as synthetic hydroxyapatite have become of great interest for research and development in the field of materials science and engineering. In spite of its biocompatibility, hydroxyapatite suffers from low mechanical strength. Aiming to improve the mechanical properties of hydroxyapatite without affecting its biocompatibility, the formation of hydroxyapatite composites with alumina (Al2O3) as a reinforcement has been studied. In this work, hydroxyapatite was synthesized via a sol–gel method. Hydroxyapatite/alumina composites (HAp/Al2O3) were prepared in different proportions to determine the best combination to be used as a controlled release system of ampicillin. The samples obtained were characterized by X-ray diffraction and scanning electron microscopy. Mechanical behavior was evaluated by diametrical compression. After characterization of the composites, the sample with the highest mechanical resistance was chosen for the incorporation and release of ampicillin. The study showed very different release profiles, indicating that the release devices prepared may be useful in clinical applications that require varying times for treatment. |
| Databáze: | OpenAIRE |
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